Thiostrepton

Overview
Catalog #	bs-82393c-1-g
Product Name	Thiostrepton
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Novel cyclopeptide antibiotic. Blocks bacterial protein synthesis by inhibition of mRNA-tRNA translocation by GTPase elongation factor G (EF-G), EF-TU(GTP)-catalyzed aa-tRNA delivery as well as the activity of initiation factor-1 (IF-2)1-2. Displays antitumor activity. Induces apoptosis and cell cycle arrest in various tumor cells via downregulation of FOXM1 expression3.
Description	CAS Number: 1393-48-2 Chemical Name: Fermentation product from Streptomyces azureus Molecular weight: 1664.91 Formula: C72H85N19O18S5 Solubility: DMSO (15 mg/ml) Chloroform (5 mg/ml) Physical Properties: Off-white solid Purity: 98% by TLC and HPLC