AS-8351

Overview
Catalog #	bs-82338c-5-mg
Product Name	AS-8351
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1
Description	CAS Number: 796-42-9 Chemical Name: 2-Hydroxy-1-naphthylaldehyde isonicotinolyhydrazone Molecular weight: 291.3 Formula: C17H13N3O2 Solubility: DMSO (45 mg/ml) DMF (30 mg/ml) Ethanol (10 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)