ISRIB

Overview
Catalog #	bs-82313c-5-mg
Product Name	ISRIB
Specifications
Storage Buffer	Off-white solid
Storage Condition	-20°C
Target
Product Information	Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2α (eIF2α) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2β.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid β-induced neuronal cell death (12.5-25 nM) with no effect on amyloid β production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
Description	CAS Number: 1597403-47-8 Chemical Name: N.N’-trans-1,4-Cyclohexanediylbis[2-(4-chlorophenoxy)acetamide Molecular weight: 451.34 Formula: C22H24Cl2N2O4 Solubility: DMSO (5 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)