SR-8278

Overview
Catalog #	bs-82288c-5-mg
Product Name	SR-8278
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	Antagonist of the nuclear heme receptor, REV-ERB. Blocks the ability of the REV-ERBα agonist, GSK4112, to enhance REV-ERB-dependent repression in a cotransfection assay.1 Decreases glucagon secretion and intracellular calcium signals in alphaTC1-9 cells and mouse primary alpha cells.2 Enhances the expression of bone morphogenetic protein genes in rat uterus endometrium stromal cells.3 Shortens the period of circadian oscillations in mature granulosa cells stimulated with or without LH.4
Description	CAS Number: 1254944-66-5 Chemical Name: 1,2,3,4-Tetrahydro-2-[[5-(methylthio)-2-thienyl]carbonyl]-3-isoquinolinecarboxylic acid ethyl ester Molecular weight: 361.49 Formula: C18H19NO3S2 Solubility: DMSO (60 mg/ml) Ethanol (35 mg/ml) Physical Properties: White waxy solid Purity: 98% by TLC, NMR (Conforms)