LY-364947

Overview
Catalog #	bs-82281c-5-mg
Product Name	LY-364947
Specifications
Storage Buffer	White or slightly yellow solid
Storage Condition	RT
Target
Product Information	Selective ALK5 inhibitor, IC50 = 59, 400 and 1400 nM for TGF-β RI, TGF-β RII and MLK-7K, respectively1. Inhibits Smad2 phosphorylation induced by TGF-β as well as fibronectin expression and MDA-MB-231 cell invasion2. Abolishes resistance of glioblastoma-initiating cells to radiation3. Cell permeable.
Description	CAS Number: 396129-53-6 Chemical Name: 4-(3-Pyridin-2-yl-1H-pyrazol-4-yl)quinolone Molecular weight: 272.31 Formula: C17H12N4 Solubility: DMSO (25 mg/ml) Physical Properties: Beige solid Purity: 98% by TLC