ML297

Overview
Catalog #	bs-82264c-5-mg
Product Name	ML297
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Selective GIRK ½ (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2 Displays antiseizure activity2 and decreases anxiety-related behavior without sedative or addictive effects3. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells.4 Brain penetrant.
Description	CAS Number: 1443246-62-5 Chemical Name: N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea Molecular weight: 328.32 Formula: C17H14F2N4O Solubility: DMSO (45 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)