NSC405020

Overview
Catalog #	bs-82259c-5-mg
Product Name	NSC405020
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	Membrane type-1 matrix metalloproteinase (MMP14 or MT1-MMP) inhibitor that prevents homodimerization and inhibits MMP14’s protumorigenic activity in vivo. (IC50 > 100 μM). Inhibition is via interaction with the hemopexin domain (PEX) of MMP14. NSC-405020 does not interfere with the catalytic activity of MT1-MMP or MMP-2. Suppresses bone erosion in a c-Fos-deficient mouse model.2 Decreases arsenic-mediated invasion of human squamous cell carcinoma HSC5 cells.3
Description	CAS Number: 7497-07-6 Chemical Name: 3,4-Dichloro-N-(1-methylbutyl)benzamide Molecular weight: 260.15 Formula: C12H15NCl2O Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)