GSK-J4

Overview
Catalog #	bs-82219c-5-mg
Product Name	GSK-J4
Specifications
Storage Buffer	Pale yellow solid
Storage Condition	-20°C
Target
Product Information	Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
Description	CAS Number: 1373423-53-0 Chemical Name: N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester Molecular weight: 417.48 Formula: C24H27N5O2 Solubility: DMSO (40 mg/ml) Ethanol (40 mg/ml) Physical Properties: Yellow waxy solid Purity: 99% by TLC, NMR (Conforms)