iCRT5

Overview
Catalog #	bs-82207c-5-mg
Product Name	iCRT5
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A selective CRT (β-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the β-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.
Description	CAS Number: 18623-44-4 Chemical Name: 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid Molecular weight: 367.44 Formula: C16H17NO5S2 Solubility: DMSO (30 mg/ml) Physical Properties: Yellow solid Purity: 98% by TLC, NMR (Conforms)