JQ1 (+/-)

Overview
Catalog #	bs-82200c-5-mg
Product Name	JQ1 (+/-)
Specifications
Storage Buffer	White solid
Storage Condition	RT
Target
Product Information	JQ1 is a potent BET bromodomain inhibitor. IC50 = 17.7, 32.6, 76.9 and 12942 nM respectively for BRD2 (N-terminal (N)), BRD4 (C-terminal (C)), BRD4 (N) and CREBBP respectively. Competitive binding by JQ1 displaces the BRD4 fusion oncoprotein from chromatin, prompting squamous differentiation and specific antiproliferative effects in BRD4-dependent cell lines and patient-derived xenograft models establishing proof-of-concept for targeting protein-protein interactions of epigenetic readers1.
Description	CAS Number: 1268524-69-1 Chemical Name: (6R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid 1,1-dimethylethyl ester Molecular weight: 457.00 Formula: C23H25ClN4O2S Solubility: DMSO (9 mg/ml) Ethanol (9 mg/ml) Physical Properties: White solid Purity: 98% by TLC, NMR (Conforms)