FQI1

Overview
Catalog #	bs-82199c-5-mg
Product Name	FQI1
Specifications
Storage Buffer	Tan solid
Storage Condition	-20°C
Target
Product Information	Inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 M). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2 In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3 Blocks LSF-stimulated activation of DNA methyltransferase 1.4 Cell permeable.
Description	CAS Number: 599151-35-6 Chemical Name: 8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one Molecular weight: 311.33 Formula: C18H17NO4 Solubility: DMSO (50 mg/ml) Ethanol (20 mg/ml) Physical Properties: White solid Purity: 98% by TLC NMR (conforms)