A83-01

Overview
Catalog #	bs-82179c-5-mg
Product Name	A83-01
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
Description	CAS Number: 909910-43-6 Chemical Name: 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide Molecular weight: 421.53 Formula: C25H19N5S Solubility: DMSO (20 mg/ml) Physical Properties: Light yellow solid Purity: 98% by TLC, NMR (Conforms)