CHIR-99021

Overview
Catalog #	bs-82151c-5-mg
Product Name	CHIR-99021
Specifications
Storage Buffer	White solid
Storage Condition	-20°C
Target
Product Information	Potent and selective inhibitor of glycogen synthase kinase-3β (GSK3β, IC50 = 5 nM) and GSK3α (IC50 = 10 nM)1. Induces osteoblastogenesis, increases mineralization and inhibits adipogenesis in ST2 cells2. Promotes replication and survival of pancreatic beta cells3. Enhances differentiation and reduces proliferation of adult human olfactory epithelium neural precursors4. Cell permeable and active in vivo.
Description	CAS Number: 252917-06-9 Chemical Name: 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(5-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile Molecular weight: 465.35 Formula: C22H18Cl2N8 Solubility: DMSO (25 mg/ml) Physical Properties: Tan solid Purity: 99% by TLC, NMR (conforms)