Xestospongin C

Overview
Catalog #	bs-82134c-10-ug
Product Name	Xestospongin C
Specifications
Storage Buffer	Yellow solid
Storage Condition	-20°C
Target
Product Information	A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM1. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling3. Cell permeable.
Description	CAS Number: 88903-69-9 Chemical Name: Natural product isolated from the marine sponge Xestospongia sp. Molecular weight: 446.71 Formula: C28H50N2O2 Solubility: DMSO (10 mg/ml) Physical Properties: Lyophilized solid Purity: 97% by TLC NMR (Conforms)