PIT-1

Overview
Catalog #	bs-82123c-10-mg
Product Name	PIT-1
Specifications
Storage Buffer	light yellow solid
Storage Condition	RT
Target
Product Information	PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
Description	CAS Number: 53501-41-0 Chemical Name: N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide Molecular weight: 351.76 Formula: C14H10ClN3O4S Solubility: DMSO (25 mg/ml) Ethanol (3 mg/ml) Physical Properties: Grey solid Purity: 98% by TLC, NMR (Conforms)