AP-18
Overview | |
Catalog # | bs-82082c-10-mg |
Product Name | AP-18 |
Specifications | |
Storage Buffer | White solid |
Storage Condition | RT |
Target | |
Product Information | TRPA1 channel blocker IC50=3.1-4.5 μM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 μM.1 Blocks TRPA1 pore dilation (IC50=10.3 μM).2 An important tool for assessing the role of TRPA1 in cell signaling and physiological processes.3-5 |
Description | CAS Number: 55224-94-7 Chemical Name: 4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime Molecular weight: 209.67 Formula: C11H12ClNO Solubility: DMSO (25 mg/ml) Ethanol (25 mg/ml) Physical Properties: White solid Purity: 98% by TLC [10% Methanol in methylene chloride, Rf = 0.60] NMR Conforms |