L-Cycloserine
Overview | |
Catalog # | bs-80467C |
Product Name | L-Cycloserine |
Specifications | |
Storage Buffer | powder |
Storage Condition | -20°C |
Target | |
Product Information | Molecular Weight:102.1 Formula:C3H6N2O2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml, warm) or in Water (up to 25 mg/ml). Chemical Name:(S)-4-Amino-3-isoxazolidinone |
Description | Down-regulates sphingolipid biosynthesis via inhibition of serine palmitoyltransferase (3-ketodihydrosphingosine synthetase)1. The L isomer was shown to be 100-fold more potent than the D isomer at inhibition of the brain microsomal enzyme1. It is a useful pharmacological agent for lowering sphingolipid levels in cells2 as well as in animal models3. Inhibition of de novo ceramide biosynthesis with L-cycloserine positively affected the senescent phenotype, restoring neuronal signaling and reducing mitochondrial dysfunction in a cortical neuronal model of senescence4. |