ZSTK474

Overview
Catalog #	bs-80440C
Product Name	ZSTK474
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:417.41 Formula:C19H21F2N7O2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming). Chemical Name:2-(2-Difluoromethylbenzoimidazol-1-yl)-4,6-dimorpholino-1,3,5-triazine
Description	Novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3Kδ most potently, with a Ki of 1.8 nM, while inhibiting the α, β and γ isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively)1. Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice2. It displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis3. Ameliorates the progression of adjuvant-induced arthritis in a rat model4.