Lenalidomide

Overview
Catalog #	bs-80431C
Product Name	Lenalidomide
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:259.26 Formula:C13H13N3O3 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:(R,S)-3-(4-Amino-1-oxo-3H-isoindol-2-yl)piperidine-2,6-dione
Description	Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic