Bosutinib

Overview
Catalog #	bs-80416C
Product Name	Bosutinib
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:530.6 Formula:C26H29Cl2N5O3 Purity:>98% Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 25 mg/ml with warming). Chemical Name:4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Description	Bosutinib is an ATP-competitive dual Src/Abl kinase inhibitor (IC50 = 1 nM)1. It potently inhibits the apoptosis-linked STE20 kinases but does not inhibit Kit or PDGFR2. Bosutinib was found to inhibit 16 of 18 imatinib-resistant mutant forms of Bcr-Abl expressed in murine myeloid cell lines, but did not inhibit T315I and V299L mutants3. Enhances retinoic acid-induced differentiation of HL-60 leukemia cells4. Suppresses migration and invasion of human breast cancer cells (IC50 = 250 nM which is also the IC50 for inhibition of cellular Src kinase activity in intact tumor cells)5.