Gliotoxin

Overview
Catalog #	bs-80394C
Product Name	Gliotoxin
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:326.4 Formula:C13H14N2O4S2 Purity:>98% Solubility:Soluble in DMSO (up to 15 mg/ml) Chemical Name:(3R,5aS,6S,10aR)-2,3,5a,6-Tetrahydro-6-hydroxy-3-(hydroxymethyl)-2-methyl-10H-3,10a-epidithiopyrazino[1,2-a]indole-1,4-dione
Description	A fungal metabolite with immunosuppressive properties: blocks phagocytosis, cytokine production and proliferation of T and B cells1. Inhibits chymotrypsin-like activity of 20S proteasome preventing IκBα degradation and preventing NF-κB degradation2. Displays antiinflammatory activity3 and blocks leukotriene B4 production via inhibition of LTA4 hydrolase4. Inhibits nuclear NOTCH2 and recovers a tumor-suppressor NOTCH3 activity in chronic lymphocytic leukemia cells5.