ST-034307
| Overview | |
| Catalog # | bs-80362C |
| Product Name | ST-034307 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:297.95 Formula:C10H4Cl4O2 Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 6 mg/ml) Chemical Name:6-Chloro-2-(trichloromethyl)-4H-1-benzopyran-4-one |
| Description | A novel selective adenylyl cyclase 1 (AC1) inhibitor, IC50=2.3 μM . Inhibits calcium2+-stimulated cAMP accumulation in HEK cells stably transfected with AC11. It was also shown to inhibit AC1 stimulated by forskolin- and Gαs-coupled receptors in HEK-AC1 cells. It enhanced μ-opioid receptor-mediated inhibition of AC1 but it blocked heterologous sensitization of AC1 caused by chronic μ-opioid receptor activation.1 Displays analgesic properties in a mouse model of inflammatory pain.1 |
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