PBIT

Overview
Catalog #	bs-80350C
Product Name	PBIT
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:241.31 Formula:C14H11NOS Purity:>98% Solubility:Soluble in DMSO (up to 24 mg/ml) or in Ethanol (up to 5 mg/ml) Chemical Name:2-(4-Methylphenyl)-1,2-benzisothiazol-3(2H)-one
Description	The JARID1 (Jumonji AT-Rich Interactive Domain 1) family of lysine demethylases demethylates the trimethylated lysine 27 in histone H3 (H3K4me3). PBIT is a potent and selective inhibitor of JARID1 (IC50 = 3, 4.9 and 6 μM for JARID1B, 1A and 1C, respectively). Selective for JARID1 over UTX and JMJD3. Treatment of cells with PBIT inhibits the demethylation of H3K4me3. It inhibits proliferation of breast cancer cell lines expressing high levels of JARID1B1.