4µ8C

Overview
Catalog #	bs-80343C
Product Name	4µ8C
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:204.18 Formula:C11H8O4 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml) Chemical Name:7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran-8-carboxaldehyde
Description	Selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50 = 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity1. Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells2. Blocks production of IL-4, IL-5 and IL-13 production in T cells3. Prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells4.