NSC33994

Overview
Catalog #	bs-80321C
Product Name	NSC33994
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:436.65 Formula:C28H42N2O2 Purity:>98% Solubility:Soluble in DMSO (up to 2 mg/ml with warming) or in Ethanol (up to 4 mg/ml with warming). Chemical Name:E-4,4’-(1,2-Diethyl-1,2-ethenediyl)bis[2-[(diethylamino)methyl]phenol
Description	A remarkably potent and selective JAK2 inhibitor (IC50 = 60 nM). Displays no effect on Src and TYK2 tyrosine kinase activity at a concentration of 25 μM1. Suppresses JAK2-V617F-mediated human pathological cell growth in vitro and in vivo2 and is concomitant with the disruption of intracellular vimentin filaments3. Reduces the tumorigenic potential of T98G glioblastoma cells in vitro and in vivo4.