PD-150606
| Overview | |
| Catalog # | bs-80310C |
| Product Name | PD-150606 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:306.12 Formula:C9H7IO2S Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 15 mg/ml). Chemical Name:(Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic acid |
| Description | A selective, cell-permeable non-peptide calpain inhibitor (Ki for μ- and m-calpains = 0.21 and 0.37 μM respectively). Acts at the calcium binding site of calpain rather than the substrate-binding site. Inhibits calpain activity in two intact cell systems. Attenuates hypoxic/hypoglycemic injury to cerebrocortical neurons in culture and excitotoxic injury to Purkinje cells in cerebellar slices1. Displays cytoprotective effects in oxidant- and calcium ionophore-induced cell death2. Some protective effects may be due to inhibition of MMP activity3. |
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