GPI-16552
| Overview | |
| Catalog # | bs-80300C |
| Product Name | GPI-16552 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:502.6 Formula:C33H30N2O3 Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in DMF (up to 25 mg/ml). Chemical Name:N-bis-(3-Phenyl-propyl)-9-oxo-fluorene-2,7-diamide |
| Description | A novel potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), IC50=1.7 μM1. Pre or post ischemia treatment (40 mg/kg) with GPI-16552 reduces brain infarct volumes in a rat model of cerebral ischemia2. It modulates the inflammatory response to ischemia/reperfusion in a rat splanchnic artery occlusion model3 and reduces the degree of spinal cord inflammation and tissue injury after experimental spinal cord trauma4. Synergizes with temozolomide in decreasing melanoma cell invasion and metastatic spreading in mice injected with B16 melanoma cells5. |
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