AI-3

Overview
Catalog #	bs-80296C
Product Name	AI-3
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:292.81 Formula:C11H13ClO3S2 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml). Chemical Name:1-Chloro-6,7-dihydro-6,6-dimethyl-3-(methylsulfonyl)-benzo[c]thiophen-4(5H)-one
Description	Activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations. Disrupts Nrf2/Keap1 and Keap1/Cul3 interactions and stabilizes Nrf2. Activates ARE in an Nrf2 and PI 3-kinase dependent manner. Cell permeable and active in vivo.