PRT-4165
| Overview | |
| Catalog # | bs-80283C |
| Product Name | PRT-4165 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:235.24 Formula:C15H9NO2 Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 6 mg/ml with warming). Chemical Name:2-(3-Pyridinylmethylene)-1H-indene-1,3(2H)-dione |
| Description | Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 μM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2α.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2 |
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