HTS01037

Overview
Catalog #	bs-80267C
Product Name	HTS01037
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:337.37 Formula:C14H11NO5S2 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) Chemical Name:4-[(3-Carboxy-1-oxo-2-propen-1-yl)amino]-[2,2’-bithiophene]-5-carboxylic acid, 5-methyl ester
Description	Inhibits fatty acid binding proteins. Inhibits lipolysis in 3T3-L1 adipocytes and reduces LPS-stimulated inflammation in cultured macrophages. Acts as an antagonist of the protein-protein interaction between AFABP/aP2 and hormone sensitive lipase but does not activate PPARγ in macrophages1. Inhibits FABP-dependent and fatty acid-stimulated leukotriene C4 biosynthesis2. Reduces intracellular free fatty acid levels, lowering macrophage inflammation and ER stress3. Reduces LPS-stimulated IL-1β secretion in a mouse model4. Inhibits VLDL-induced foam cell formation5.