GSK-1702934A
| Overview | |
| Catalog # | bs-80261C |
| Product Name | GSK-1702934A |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:396.5 Formula:C22H26N3O2S Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming) Chemical Name:1-(1-(5,6,7,8-Tetrahydro=4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one |
| Description | TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 µM and 0.44 µM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1 µM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1 µM1. Induces proarrhythmic and inotropic effects in TRPC3-overexpressing myocytes2. |
Powered by Bioz