ML-SA1

Overview
Catalog #	bs-80256C
Product Name	ML-SA1
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:362.43 Formula:C22H22N2O3 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml). Chemical Name:2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Description	TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4