CCG-4986
| Overview | |
| Catalog # | bs-80252C |
| Product Name | CCG-4986 |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | -20°C |
| Target | |
| Product Information | Molecular Weight:374.8 Formula:C13H11ClN2O5S2 Purity:>98% Solubility:Soluble in DMSO (up to 60 mg/ml), or in Ethanol (up to 5 mg/ml with warming). Chemical Name:Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate |
| Description | The first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS41. It covalently2-3 modifies RGS4 by inhibiting its interaction with Gα (IC50 = 3-5 µM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling4. A novel tool for exploring the involvement of RGS4 in physiological processes5. |
Powered by Bioz