Gue1654

Overview
Catalog #	bs-80248C
Product Name	Gue1654
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:447.6 Formula:C23H17N3OS3 Purity:>98% Solubility:Soluble in DMSO (up to 40 mg/ml with warming). Chemical Name:N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
Description	Gue1654 is a biased antagonist for the oxoeicosanoid receptor 1 (OXE-R, GPR170)1, the receptor for 5-Oxo-ETE, a proinflammatory eicosanoid2. It selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R1,3. Gue1654 alleviated coronary artery ligation-induced ischemic myocardial injury in a mouse model4.