GSK-J1

Overview
Catalog #	bs-80228C
Product Name	GSK-J1
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:389.46 Formula:C22H23N5O2 Purity:>98% Solubility:Soluble in DMSO (up to 20 mg/ml). Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine
Description	Potent and selective inhibitor of jumonji H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM, human JMJD3). This is the first known inhibitor selective for the H3K27me3-specific JMJ subfamily which binds to the active catalytic site of the enzyme. The COOH group confers cell impermeability and as such is useful as a standard in in vitro assays. A cell permeable ethyl ester analog is also available.