FQI1

Overview
Catalog #	bs-80209C
Product Name	FQI1
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:311.33 Formula:C18H17NO4 Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming) Chemical Name:8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinoline-6(5H)-one
Description	Inhibitor of transcription factor LSF specifically targeting its DNA binding and corresponding transcriptional activity (IC50=2.1 M). Rapidly induces apoptosis in an aggressive hepatocellular carcinoma (HCC) cell line and dramatically inhibits tumor growth in a mouse xenograft model with no general tissue cytotoxicity.1,2 In human HCC cells, FQI1 induced mitotic arrest with an accompanying increase in cyclin B1.3 Blocks LSF-stimulated activation of DNA methyltransferase 1.4 Cell permeable.