PIT-1

Overview
Catalog #	bs-80126C
Product Name	PIT-1
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:351.76 Formula:C14H10ClN3O4S Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 3 mg/ml). Chemical Name:N-[[(3-Chloro-2-hydroxy-5-nitrophenyl)amino]thioxomethyl]benzamide
Description	PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 μM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.