KB-R7943 mesylate
| Overview | |
| Catalog # | bs-80109C |
| Product Name | KB-R7943 mesylate |
| Specifications | |
| Storage Buffer | powder |
| Storage Condition | RT |
| Target | |
| Product Information | Molecular Weight:427.49 Formula:C16H17N3O3S ∙ CH3SO3H Purity:>98% Solubility:Soluble in DMSO (up to 50 mg/ml). Chemical Name:2-[2-[4-(4-Nitrobenzyloxy)phenyl]ethyl]isothioures mesylate |
| Description | KB-R7943 is a potent and selective inhibitor of the reversed Na+/Ca2+ exchanger (NCE or NCX; IC50’s = 1.2-2.4 µM in cardiomyocytes, smooth muscle cells, NCX1-transfected fibroblasts1; 0.7µM in cultured rat forebrain2). KB-R7943 has also been shown to inhibit the mitochondrial Ca2+ uniporter (MCU) – Ki = 5.5 µM.3 Recently shown to inhibit complex I in the mitochondrial respiratory chain (IC50 = 11.4 µM) and block NMDA receptors (IC50 = 13.4 µM).4 |
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