2-Chloroadenosine

Overview
Catalog #	bs-80105C
Product Name	2-Chloroadenosine
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:301.7 Formula:C10H12ClN5O4 Purity:>95% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 7 mg/ml). Chemical Name:6-Amino-2-chloropurine riboside
Description	A metabolically stable adenosine analog that acts as an agonist at A1, A2a, and A3 adenosine receptors (Ki = 300, 80, 1900 nM)1. 2-Chloroadenosine is also a bidirectional substrate for equilibrative nucleoside transporter 4 (ENT4) in acidic conditions2. At 100 µM, it causes accumulation of cAMP in neonatal mouse osteoblast-like cells3. Reduces intracellular ATP levels through both ATP consumption and AMP deamination, and induces apoptosis in leukemic B-cells and rheumatoid fibroblasts4,5.