P7C3

Overview
Catalog #	bs-80099C
Product Name	P7C3
Specifications
Storage Buffer	powder
Storage Condition	-20°C
Target
Product Information	Molecular Weight:474.20 Formula:C21H18Br2N2O Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml). Chemical Name:1-(3,6-Dibromo-9H-carbazol-9-yl)-3-(phenylamino)propan-2-ol
Description	P7C3 exerts proneurogenic activity by protecting newborn neurons from apoptosis. Prolonged administration to aged rats impedes neuronal death and preserves cognitive capacity.1 Delays disease progression in G93A-SOD2 mutant mouse model of amyotrophic lateral sclerosis.2 Blocks MPTP-mediated cell death of dopaminergic neurons in the substantia nigra of adult mice, a model of Parkinson disease.3 Restores hippocampal neurogenesis in a mouse model of Down Syndrome.4 The mechanism of action involves activation of nicotinamide phosphoribosyltransferase (NAMPT) with concomitant increase of intracellular levels of NAD.5 Active in vivo.