AP-18

Overview
Catalog #	bs-80082C
Product Name	AP-18
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:209.67 Formula:C11H12ClNO Purity:>98% Solubility:Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml). Chemical Name:4-(4-Chlorophenyl)-3-methylbut-3-en-2-oxime
Description	TRPA1 channel blocker IC50=3.1-4.5 µM in various cell lines. Reduces cinnamaldehyde-induced nociception in vivo and blocks cold- and mustard oil-induced activation of mouse TRPA1 but not capsaicin-induced activation. Does not block TRPV1, V2, V3, V4 or M8 at concentrations up to 50 µM1. Blocks TRPA1 pore dilation (IC50=10.3 µM)2. An important tool for assessing the role of TRPA1 in cell signaling and physiological processes3-5.