Tesmilifene HCl

Overview
Catalog #	bs-80056C
Product Name	Tesmilifene HCl
Specifications
Storage Buffer	powder
Storage Condition	RT
Target
Product Information	Molecular Weight:283.42 Formula:C19H25NO Purity:>98% Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 75 mg/ml). Chemical Name:N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine hydrochloride
Description	Tesmilifene, an analog of tamoxifen, acts as a chemopotentiator and antineoplastic agent and was developed for the treatment of breast cancer but never marketed1. It binds with high affinity to the anti-estrogen binding site (AEBS) in rat liver microsomes but does not bind to the estrogen receptor (at or below 10 µM) 2. Displaces histamine from AEBS, an activity which correlates with its cytotoxic effects on breast cancer cells2. Enhances the cytotoxicity of taxol, epirubicin, doxorubicin and vinorelbine in multidrug resistance cell lines3. It has been shown to increase the permeability of the blood-brain and blood-glioma barrier in culture and animal models by modifying brain endothelial functions4.