Andrographolide

Overview
Catalog #	bs-75887c-500mg
Product Name	Andrographolide
Specifications
Storage Buffer	Powder
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 5508-58-7 Molecular formula: C20H30O5 Molecular weight: 350.455 Purity: >98% (HPLC) Appearance: White to light yellow powder. Solubility: Soluble in chloroform, DMF (15mg/ml) or DMSO (2mg/ml). InChiKey: BOJKULTULYSRAS-OTESTREVSA-N SMILES: C=C1CC[C@@]([C@@](CO)(C)[C@H](O)CC2)([H])[C@]2(C)[C@@H]1C/C=C3C(OC[C@H]/3O)=O
Description	Andrographolide, a bioactive diterpene lactone, is the main constituent of Andrographis paniculata, a plant used in traditional medicines. It is known to have different biological properties such as anti-inflammatory, immunosuppressive, antidiabetic, antihyperglycemic, antibacterial, antioxidant, antinoniceptive, antimalarial, anticancer and hepatoprotective activity. It also shows potent anti-viral effect against dengue virus. It blocks T-cell proliferation and the proliferation of several cancer cell lines in vitro. It acts as an irreversible antagonist of NF-kappa and AP-1 (IC50 < 15 µM) activation, and prevents in vitro and in vivo T cell activation.