Necrosulfonamide

Overview
Catalog #	bs-75589c-5mg
Product Name	Necrosulfonamide
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1360614-48-7 Molecular formula: C18H15N5O6S2 Molecular weight: 461.5 Purity: >95% Appearance: Off-white to yellow solid. Solubility: Soluble in DMSO (20mg/ml) or DMF (20mg/ml). Insoluble in water. InChiKey: FNPPHVLYVGMZMZ-XBXARRHUSA-N SMILES: O=C(/C=C/C1=CC=C([N+]([O-])=O)S1)NC2=CC=C(S(NC3=C(OC)N=CC=N3)(=O)=O)C=C2
Description	Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of gasdermin D that works well for mice studies. It binds directly to gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death.