MLN4924 [NAE Inhibitor]

Overview
Catalog #	bs-75587c-5mg
Product Name	MLN4924 [NAE Inhibitor]
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 905579-51-3 Molecular formula: C21H25N5O4S . H2O Molecular weight: 443.5 . 18.0 Purity: >99% Appearance: White solid. Solubility: Soluble in DMSO (30mg/ml), ethanol (10mg/ml) or DMF (20mg/ml). Insoluble in water. InChiKey: MPUQHZXIXSTTDU-QXGSTGNESA-N SMILES: [H][C@@]1(C[C@H](O)[C@H](COS(N)(=O)=O)C1)N1C=CC2=C(N[C@H]3CCC4=CC=CC=C34)N=CN=C12
Description	Adenosine 5'-monophosphate (AMP) analog. Potent, selective and cell permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE) (IC50=4.7nM). NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates relevant to cancer cell survival. Anticancer agent with in vitro and in vivo activity. By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis. Inhibits related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2µM, respectively. Angiogenesis inhibitor and autophagy inducer. Antiviral agent. Exhibited pronounced antiviral activity against mouse and human cytomegalovirus, herpes simplex virus (HSV)-1 (including multi-drug resistant clinical isolates), HSV-2, adeno and influenza viruses.