UK 5099

Overview
Catalog #	bs-75578c-1mg
Product Name	UK 5099
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 56396-35-1 Molecular formula: C18H12N2O2 Molecular weight: 288.3 Purity: >98% (HPLC) Appearance: Off-white to yellow solid. Solubility: Soluble in DMSO (20mg/ml) or DMF (10mg/ml). Sparingly soluble in aqueous buffers. InChiKey: BIZNHCWFGNKBBZ-JLHYYAGUSA-N SMILES: N#C/C(C(O)=O)=C\C1=CN(C2=CC=CC=C2)C3=CC=CC=C31
Description	Potent and specific inhibitor of the mitochondrial pyruvate carrier (MPC), blocking pyruvate from entering the mitochondria, consequently promoting lactate production. Inhibitor of tricarboxylic acid (TCA) cycle. Plasma membrane monocarboxylate transporters (MCTs) inhibitor, but with Ki values some two or three orders of magnitude higher than those for the inhibition of the MPC. Inhibits mitochondrial lactate and pyruvate transport. Decreases glycolysis. Useful agent for immunometabolism research.