TEPP46 [ML-265]

Overview
Catalog #	bs-75574c-1mg
Product Name	TEPP46 [ML-265]
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1221186-53-3 Molecular formula: C17H16N4O2S2 Molecular weight: 372.5 Purity: >95% Appearance: White to off-white solid. Solubility: Soluble in DMSO (10mg/ml). Insoluble in water. InChiKey: ZWKJWVSEDISQIS-UHFFFAOYSA-N SMILES: CS(C1=CC(N2C)=C(C3=C2C(N(N=C3)CC4=CC(N)=CC=C4)=O)S1)=O
Description	Potent and selective cell permeable pyruvate kinase M2 (PKM2) activator with little or no activity versus PKM1, PKL and PKR. Useful agent for immunometabolism research. Anticancer (reducing tumor sizes in mice) and anti-inflammatory agent. Shown to bind the enzyme PKM2 to promote formation of stable, enzymatically-active tetramers, thereby promoting the last rate-limiting step of glycolysis, converting PEP to pyruvate. In addition, it prevents PKM2 translocation to the nucleus resulting in reduced glycolysis and HIF-1alpha activation, causing diminished Warburg effect and IL-1beta production.