Ruxolitinib . phosphate salt

Overview
Catalog #	bs-75541c-5mg
Product Name	Ruxolitinib . phosphate salt
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 1092939-17-7 Molecular formula: C17H18N6 . H3O4P Molecular weight: 306.4 . 98.0 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO (>100mg/ml) and water (8mg/ml). Slightly soluble in 100% ethanol. InChiKey: JFMWPOCYMYGEDM-XFULWGLBSA-N SMILES: N#CC[C@H](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O
Description	Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19).