Ruxolitinib (free base)
| Overview | |
| Catalog # | bs-75523c-5mg |
| Product Name | Ruxolitinib (free base) |
| Specifications | |
| Storage Buffer | Solid |
| Storage Condition | Stable for 2 years after receipt when stored at -20°C. |
| Target | |
| Product Information | CAS Number: 941678-49-5 Molecular formula: C17H18N6 Molecular weight: 306.4 Purity: >98% (HPLC) Appearance: White to off-white solid. Solubility: Soluble in DMSO or ethanol. Insoluble in water. InChiKey: HFNKQEVNSGCOJV-OAHLLOKOSA-N SMILES: N#CC[C@H](C1CCCC1)N1C=C(C=N1)C1=NC=NC2=C1C=CN2 |
| Description | Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19). |
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