Glyburide (USP)

Overview
Catalog #	bs-75514c-1g
Product Name	Glyburide (USP)
Specifications
Storage Buffer	Solid
Storage Condition	Stable for 2 years after receipt when stored at -20°C.
Target
Product Information	CAS Number: 10238-21-8 Molecular formula: C23H28ClN3O5S Molecular weight: 494 Purity: >98% Appearance: White to off-white solid. Solubility: Soluble in DMSO. Slightly soluble (<1mg/ml) in ethanol (gentle warming). InChiKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N SMILES: COC1=C(C=C(Cl)C=C1)C(=O)NCCC1=CC=C(C=C1)S(=O)(=O)NC(=O)NC1CCCCC1
Description	Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels (KATP) inhibitory regulatory subunit sulfonylurea receptor 1 (SUR1). Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette (ABC) transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.